In order for F5 load balancing to be configured properly, the Virtual IP address (VIP) of the LTM server must be set as the loopback interface on DNS/DHCP Servers in the F5 pool.
If there's more than one VIP associated with an LTM server, all of those IP addresses must be set as loopback addresses on the DNS/DHCP Servers in the F5 pool.
The VIP of the LTM server must be obtained when configuring the LTM server on the F5 management interface. For more information, refer to https://f5.com/products/big-ip/local-traffic-manager-ltm.
To configure loopback addresses: